Blood, Antibodies and Dilemmas: Auto-Immune Hemolytic Anemia in Transfusion Medicine


22 January, 2026

AUTOIMMUNE HAEMOLYTIC ANAEMIA (AIHA):  

AIHA THROUGH TIME

  • 1904 – Donath & Landsteiner Described Cold‑induced Hemolysis
  • 1945 – Coombs, Mourant & Race Developed The Coombs Test, Enabling Dx Of AIHA.
  • Mid‑20th Century – Classified Into Warm, Cold & Mixed Types
  • Modern Era – Advances In Immunohematology Improved Understanding Of Pathophysiology, Serology, And Transfusion Management.

A TRANSFUSION MEDICINE MAZE

  • Autoimmune Haemolytic Anemia (AIHA) creates one of the most complex challenges in transfusion medicine—where autoantibodies interfere with Blood Grouping, Antibody Screening & Crossmatching
  • Managing AIHA requires navigating this immunohaematological maze to provide safe and timely transfusion, even when fully compatible blood is unavailable.
  • Operating Procedure of Maglumi...

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