Khwaja Yunus Ali Medical College & Hospital
Department of Transfusion Medicine

NOTICE

Date: 28/01/2026

All faculty members of the Department of Transfusion Medicine are hereby requested to engage in regular research activities alongside routine departmental academic and service activities, as evidence of professional development and enhancement of academic qualifications.

For the purpose of career advancement, professional competency, and promotion, it is essential to have publications of original research articles as the Principal Author in recognized journals.

Your sincere cooperation in this regard is highly expected.

Prof. Dr. Muhammad Mahbub-ul Alam
Professor & Head
Department of Transfusion Medicine

Note:
If required, you may seek assistance in selecting your research area from the attached list of suggested research topics.

TRANSFUSION MEDICINE (Research Area):

I. Blood Donor Management & Behavioral

1. Motivation factors for voluntary non-remunerated blood donors
2. Donor deferral causes and their reduction strategies
3. Knowledge–Attitude–Practice (KAP) study on blood donation
4. Impact of social media campaigns on donor retention
5. Female blood donor participation barriers

II. Patient Blood Management (PBM)

1. Effectiveness of restrictive vs liberal transfusion strategy
2. Pre-operative anemia prevalence & management
3. Transfusion audit and appropriateness of blood use
4. PBM implementation challenges in tertiary hospitals
5. Cost reduction through PBM protocols
6. Donor deferral patterns and their impact on blood supply
7. Pre-operative anemia prevalence and transfusion requirements
8. Knowledge and practice of Patient Blood Management among clinicians
9. Restrictive vs liberal transfusion strategy in medical ICU patients
10. Effect of transfusion timing on outcomes in severe anemia

III. Platelet & Plasma Research

1. Random donor platelets vs single donor apheresis platelets
2. Platelet transfusion thresholds in dengue patients
3. Fresh frozen plasma misuse patterns
4. Plasma transfusion in liver disease—outcome analysis

IV. Transfusion Reactions & Hemovigilance

1. Incidence & types of acute transfusion reactions
2. Under-reporting of transfusion reactions
3. Knowledge of hemovigilance among healthcare workers
4. Implementation of national hemovigilance system

V. Advanced Immunohematology & Molecular Research

1. Molecular characterization of blood group antigens in Bangladeshi population
2. Genetic predictors of red cell alloimmunization
3. Role of cytokine polymorphisms in transfusion reactions
4. Red cell alloimmunization profile in chronically transfused patients
5. Clinical impact of leukoreduced vs non-leukoreduced RBC transfusion
6. Platelet refractoriness: role of HLA antibodies
7. Autoimmune hemolysis following repeated transfusions
8. Transfusion-Related Immunomodulation (TRIM) and infection risk
9. Alloimmunization patterns in multi-transfused patients (thalassemia, oncology)
10. Role of leukoreduction in reducing febrile reactions & CMV transmission
11. HLA/HPA antibody prevalence in platelet-refractory patients
12. Autoantibodies induced after repeated transfusion

VI. Component Quality & Storage Research

1. Biochemical changes in stored RBCs and post-transfusion hemoglobin response
2. Platelet storage lesion assessment and clinical efficacy correlation
3. Comparison of platelet yield and reactions: RDP vs SDP
4. Biochemical and morphological changes during RBC storage (storage lesion)
5. Comparison of CPDA-1 vs SAGM stored RBCs
6. Effect of storage duration on post-transfusion hemoglobin increment
7. Platelet storage lesions & swirling score correlation
8. Plasma quality after different freezing techniques
9. Clinical outcomes of component therapy vs whole blood
10. Awareness of component therapy among clinicians
11. Component utilization pattern in emergency & ICU
12. Wastage analysis of blood components

VII. TTIs & Safety Topics

1. Seroprevalence of transfusion-transmitted infections among voluntary vs replacement donors
2. Occult HBV infection among HBsAg-negative blood donors
3. Residual risk of TTIs using ELISA-based screening
4. Residual risk of HBV, HCV, HIV in screened blood
5. Occult HBV infection in blood donors
6. Syphilis and malaria trends among voluntary vs replacement donors
7. NAT vs ELISA cost-effectiveness analysis
8. Seasonal variation of TTIs in Bangladesh

VIII. Special Population Transfusion

1. Transfusion practices in thalassemia patients
2. Neonatal transfusion thresholds
3. Massive transfusion protocols in trauma
4. Obstetric transfusion practices and outcomes

IX. Ethics, Law & Policy in Transfusion Medicine

1. Ethical challenges in blood donation
2. Legal framework of blood transfusion services
3. Consent practices for transfusion
4. Blood safety regulations comparison (Bangladesh vs WHO standards)

X. National-Level Transfusion Safety Research

1. Nationwide hemovigilance system: implementation and outcome evaluation
2. Cost-effectiveness of NAT vs ELISA screening in Bangladesh
3. Long-term impact of voluntary blood donation on TTI reduction

XI. Innovation & Indigenous Production 

1. Development and validation of locally produced Anti-Human Globulin (AHG)
2. In-house reagent RBC panel development for antibody screening
3. Cold chain optimization models for blood storage in tropical climates
4. Cost-effective blood grouping reagents

XII. AI & Digital Transfusion Medicine 

1. Machine learning models to predict blood demand and wastage
2. AI-based donor deferral prediction system
3. Digital crossmatch and error-reduction algorithms
4. AI-based prediction of blood demand
5. Machine learning for donor deferral prediction
6. Digital cross-match error reduction systems
7. Smart blood inventory management models

XIII. Miscellaneous

1. Pattern of transfusion reactions in a tertiary care hospital
2. Appropriateness of blood component utilization in medical & surgical wards
3. Prevalence of alloimmunization in multi-transfused thalassemia patients
4. Transfusion practices in obstetric hemorrhage and maternal outcomes
5. Audit of Fresh Frozen Plasma usage in ICU settings